Research Report: Antibiotic Resistance Increases in Hospitalized Horses Even When No Antibiotics Are Administered

by Fran Jurga | 22 September 2009 | The Jurga Report at Equisearch.com

A team of researchers working at Philip Leverhulme Equine Hospital at the University of Liverpool have discovered that Escherichia coli (E. coli) bacteria in a horse's intestine appear to acquire antibiotic resistance while a horse is hospitalized.

E. coli is a bacterium that is commonly found in the lower intestine of animals. Most E. coli strains are harmless and are part of the normal flora of the gut.

The researchers found a significant increase in multiple drug resistance in E. coli samples isolated from horses' feces after a period of hospitalization.

Research team leader Adele Williams (shown in photo) received funding from British equine charity The Horse Trust and presented her research earlier this year at the European College of Equine Internal Medicine Congress.

Williams and fellow researchers collected fecal samples from randomly selected horses over an 18 month period between 2006 and 2008 when the horse was admitted, and again after the horse had been hospitalized for seven days. The selected horses included horses treated and not treated with antibiotics before and during hospitalization.

E. coli bacteria cultured from the samples were tested for their sensitivity to eight antibiotics (neomycin, ampicillin, ceftiofur, gentamicin, chloramphenicol, ciprofloxacin, tetracycline and trimethoprim) using the Kirby-Bauer disk diffusion method. The antibiotics chloramphenicol and tetracycline are not used at the hospital.

The researchers found a significant increase in resistance during the week's hospitalization for seven of the eight antibiotics; no significant difference was found for neomycin. Antibiotic resistance increased even in horses not treated with antibiotics and to antibiotics that are not used in the hospital.

This increase may be due to the transfer of antibiotic resistant genes as a result of selection pressure for antibiotic resistance in the hospital environment, or it may be because the number of resistant E. coli is greatly increased due to selective pressure so that they are much easier to detect, or that resistant isolates have been acquired from the environment. Further research is needed to understand the source of antibiotic resistance in the environment.

"Pathogenic bacteria are likely to be exposed to the same selection pressures or could receive the same resistant genes, so it is vital we improve hygiene in equine hospitals and reduce the overuse of antibiotics," said Williams. "People who work in equine hospitals need to pay strict attention to hygiene and should reserve antibiotics for essential cases only."

Headshaker Horses, Head Here for Resources and Research

by Fran Jurga | 19 June 2009 | The Jurga Report at Equisearch.com

Sometimes I finish writing an article for a magazine or a post for this blog and I look at my desk in amazement: piles of books, files strewn everywhere, journals falling on the floor, three monitor screens flashing information. Is it information overload or is it...information nirvana?

If you're like me, you haven't given up on books and files and journals and notes from conferences to do your research on your horse's health problems. But you love the ease of surfing the net to make sure that there's nothing new that you've missed, providing you can trust the source.

But in my library I can go back and research horsecare as it was practiced 100 years ago or 50 years ago or 25 years ago, with the same ease that the internet carries me deeper and deeper into the Right Now.

One condition in horses that brings many people to The Jurga Report and lots of other sites is the problem called headshaking. It's usually getting worse in horses this time of year, which is why I've put this post together now. The bright sunlight seems to irritate headshaker horses, and they're going to it now. When I go to shows and events now, I see more and more horses with those discreet little nets over their noses, and I'm so glad if they are working.

Headshaking is a subject that fascinates all of us, perhaps because it still eludes explanation. We really don't understand it, but so many of us have been around a horse that has this problem, that we've spent a lot of time pondering it. How many truly great horses have had performance careers curtailed because of headshaking? And how many horses in general just could live a happier, less stressful life without the annoyance of headshaking?

A question that really bothers me is why I don't read more about headshaking in the old books. Did they have a secret remedy that didn't survive into the modern times? Or was headshaking simply not as common then as it is now? And why does it seem to be more common each year?

The University of Lincoln in England has created the most comprehensive resource that I've seen on the problem, and they include both their own research and others. Click here to go there and have a look, but be prepared to spend some time.

This group of researchers has surveyed owners of headshaker horses through a project called the National Equine Headshaking Survey and created a site that is absolutely overflowing with literature citations, links, video, illustrations, and advice for owners. It's very inspiring and would make a great model for anyone considering an information-based site on a horse health problem. They've done a great job.

Headshaking is a seasonal problem for many horses, and the new lightweight nosenets are giving some relief, so I hope you will check those out if you haven't already. The University of Liverpool vet hospital has a page about their program of surgery for treatment of headshaking as a form of neuropathy.

Medication, nasal sprays, homeopathic Capstar...all are options that work for some horses, but there still doesn't seem to be one solution that works for all horses and fits the budgets of all owners.

I'm looking forward to that Eureka! day when we can post the news that a definitive answer to the headshaking mystery has been found. In the meantime, the University of Lincoln's web site comes very close and they are so sympathetic to horses suffering from headshaking that you feel that you truly do have a friend out there on the web. And your headshaking horse does, too.

Photo credit: Stock Exchange

What's Killing England's Fell Ponies? Charity Funding for Research Intends to Find Out

Fell ponies look like miniature Freisian horses, but look again: this is a unique breed with a long and glorious history. With long feathers and arched necks, they make the loveliest children's ponies, and the sight of them wandering their native Cumbrian countryside is the stuff that wild horse legends are made of.

But their numbers have dropped since World War II, and the gene pool has shrunken to a bottlenecked puddle. Can this breed be saved? The Horse Trust, a UK charity, has given a donation of more than US$200,000 to the Animal Health Trust, a research center known for its work on strangles and orthopedic problems in horses, and the University of Liverpool. The charity has charged them with the task of finding out how to stop Fells Pony Syndrome (FPS).

FPS is a severe immune system disorder that results in the death of some of the newborn foals, further shrinking the breeding stock available to help the breed survive. The breed is listed as "at risk" by the Rare Breeds Survival Trust.

Foals affected with FPS appear normal at birth but within a few weeks begin to lose condition and suffer diarrhea, coughing and weight loss. Severe anemia and immune dysfunction follows, leading to wasting and finally death. The disease is always fatal.

Studbook analysis and knowledge of affected foals strongly suggests that this is an inherited disease caused by an autosomal recessive genetic mutation. The problem may trace to a single stallion who was a dominant force in the breed. A DNA-based test for this mutation would enable carriers of FPS to be identified and the conception of affected foals prevented.

As well as identifying carriers in the Fell pony population, the project will be used to identify any carriers in other breeds which have been involved in the extensive outbreeding of Fell ponies over the years.

“Breeders are supportive of our attempt to develop a diagnostic test which will help to prevent carrier-carrier matings, one in four of which results in an affected foal,” says project leader Dr June Swinburne, senior post-doctoral equine molecular geneticist at the Animal Health Trust Centre for Preventive Medicine. “Foals affected by the condition inherit an incurable genetic defect which results in severe wasting and a profound anaemia together with multiple infections. Veterinary intervention is in vain and once the condition is diagnosed foals are often euthanized. The gradual but relentless decline in these foals leaves both veterinary surgeons and breeders powerless."

According to the Horse Trust, FPS at the moment is restricted to the Fell pony population but could spread to other breeds at any time. Indeed it may be possible that carriers of the condition already exist in other breeds which have interbred with the Fell pony over many years.

Another rare breed, the Dales pony, and other native British breeds will be randomly tested to detect any further penetration of the defect into the equine population.

To learn more: The Horse Trust has one of the best horse charity web sites anywhere on the web. This remarkably generous and insightful organization funds research and welfare projects that benefit horses all over the world, not just in Britain. The Horse Trust was formerly known as the Home of Rest for Horses and has a long tradition of recognizing the welfare and health needs of horses.

The Fell Pony Society is trying to cope with the devastation of their breeding stock and preserve this lovely breed of pony, which dates all the way to the Roman occupation of Britain.

Photo from the Fell Pony Society.